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Aldo Roda

Date and place of birth: 07/04/1949, Minerbio (Bologna), Italy
Citizenship: Italian
Home Address: via Saragozza 18, 40123 Bologna, Italy

Office Address: Analytical-Bioanalytical Laboratory
Department of Pharmaceutical Sciences,
Alma Mater Studiorum-University of Bologna
Via Belmeloro 6, 40126 Bologna, Italy

Tel. +39-051-343398 Fax +39-051-343398
Email. aldo.roda@unibo.it
Web page. www.anchem.unibo.it
Current Position: Full professor of Analytical Chemistry, University of Bologna, Italy

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Education and Training

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1978 Postgraduate Ph.D. in Analytical Chemistry, University of Bologna: Magna Cum Laude

bullet1973 Graduated in Chemistry, University of Bologna: Magna Cum Laude

University Career

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1973-78 Research Assistant, University of Bologna

bullet1978-86 Lecturer in Inorganic Chemistry and Clinical Chemistry, University of Bologna

Faculty Appointments

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1992- present Full professor of Analytical Chemistry, University of Bologna

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1990-92 Full professor of Medicinal Chemistry, University of Bologna

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1986-90 Full professor of Analytical Chemistry, University of Messina

Additional Experience

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1992 Visiting professor at the University of California, San Diego. Exchange visitor program between University of Bologna and University of California.

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1984 Visiting Scholar at the University of California, San Diego, Department of Analytical Chemistry and Medicine.

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1982 Visiting professorship at the Academy of Science, Republic of China.

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1981 Visiting Scholar at the University of California, San Diego, Department of Medicine and Chemistry.

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1979 Sabbatical leave to collaborate with the Gastroenterology Unit, Montefiore Hospital, University of Pittsburgh, USA

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1975 Visiting Fellow at the Mayo Clinic, Gastroenterology Unity, Rochester, MN, USA

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1974 Postgraduate visit to the Department of Gastroenterology, Guys Hospital, University of London, England

Memberships in Professional and Scientific Societies

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2009-present Member of the Executive Board of the Istituto Nazionale Biostrutture e Biosistemi (INBB), Representative for the Biotechnology section

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2005-present Member of “Accademia delle Scienze dell’Istituto di Bologna” Italy

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2003-2006 President of the Division of Analytical Chemistry, of the Italian Society of Chemistry, SCI.

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2002-2004 Past President and actually member of the advisory board of the "International Society for Bioluminescence and Chemiluminescence" (ISBC).

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2000-2006 Chairman of Bioanalytical Group of the Italian Society of Chemistry

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1986-1992 IUPAC delegate for Italy Division of Clinical Chemistry

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1984-1990 Member of the Advisory Board of the Italian Society of Clinical Chemistry (SIBIOC)

Editorial Positions and Activity

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European Editor of "Luminescence - The Journal of Biological and Chemical Luminescence" (John Wiley & Sons, Ltd).

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Regional Editor and Member of the Editorial Board of “Analytical and Bioanalytical Chemistry", Springer

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Member of the Editorial Board of "Agro-Industrial Research”, ISCI, Bologna

Personal skills and expertise

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Mother tongue: Italian

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Reading skills well: English and French

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Writing skills good: English, basic French

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Verbal skills good: English, basic French

Organizational skills and competences (selected)

    Scientific events

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President of the organizing committee of the XIII International Symposium on Luminescence Spectrometry - Detection Techniques in Biomedical, Environmental and Food Analysis- ISLS2008, Bologna, Italy September 2008

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Co-chairman of the Analytical Chemistry sessions of the 41st IUPAC World Chemistry Congress, Turin, August 5-11, 2007

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President of the organizing committee of the 10th International Symposium on Bioluminescence and Chemiluminescence, Bologna 4-8 September 1998

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Member of the organizing committee of EUROANALYSIS IX, September 1-7, 1996

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President of the organizing committee of the 22nd National Congress of the Italial Society of Clinical Chemistry SIBIOC, Bologna October 16-19, 1990

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Many others workshops, scientific events, round tables have been organized

Technical skills and expertise

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Member of the International Scientific Review Committee for the Technology Development Competition, Genome Canada (2007)

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Member of the Expert Panel of the Italian Ministry of Research, Health, Agriculture and Industry for projects and grant evaluation.

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Member of the EU: Euro Bachelor program: evaluation of University facilities, teaching program, credits and logistic.

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Expert in drug abuse analysis and forensic chemistry for Court.

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Expert in qualitative and quantitative chemical analyses employing official validated methods for public and private institutions. Almost all the bio-analytical techniques are available in the laboratory including mass spectrometry.

Consulting and collaboration (selected)

    Diagnostics:

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A standard meal (muffin) labelled with 13C-Octanoic acid was developed for the measurement of gastric emptying time of solid meals and is distributed by Sofar spa Milan, Italy.

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Technology transfer on Immunological methods (RIA, EIA) prototype and kit development. Kits and procedure developed in the lab were introduced in the clinical diagnostic marked by company like Medical System, Clone System, distributed by IFCI spa, Italy.

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A urea 13C kit (Expirobacter Pylori) for the diagnosis of Helicibacter infection is in the market by Maffioli spa, Milan

    Pharmaceuticals Companies:

    Collaboration with National and International Pharmaceutical Companies (selection):

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Segix Italia (Rome): Development and application of analytical methods based on HPLC-ES-MS/MS for determining drugs and metabolites in biological samples collected from “in vivo” animal studies, 2009-present

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Sofar Spa (Milan): Development and validation of an HPLC-ESI-MS/MS method for the determination of mesalazine and its main metabolite in human plasma; application to a bioequivalence study, 2007

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Intercept Pharmaceuticals Inc. (San Diego, USA): Development of HPLC-ES-MS/MS methods for pharmacokinetics studies of new bile acid derivatives and for the identification of metabolites in animal studies and structure-activity relationship studies, 2005-present

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Rottapharm (Milan): Development and validation of HPLC-ES-MS/MS method for the analysis of Glucosamine in human and animal biological samples; development of HPLC-ES-MS/MS and UPLC-UV methods for new molecules of pharmaceutical interest in plasma samples, 2003-present

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Nicox (Nice, France): Development of analytical hyphenated methodology based on HPLC coupled with mass spectrometry for the identification of impurities in drugs and metabolites in biological fluids, 2001-2005.

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Bayer Spa (Milan): Studies on the drug release of trandermic FANS formulations, Aspirin and other molecules pharmacokinetics. Development of suitable analytical methods of analysis, 2002

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Sanofi-Avensis (ex Midy-Sanofi-Sinthelabo, Milan): Studies on Ursodeoxycholic acid: metabolism, activity, Pharmacokinetics. Design of: new formulation for intravenously administration Editor of a scientific book on Ursodeoxycholic acid, 1997-2002

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ex Ciba Corporation (Summit, USA): SAR studies including pharmacokinetics and metabolism of new chemical entities (Patents), 1990-2000

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Sofar Spa (Milan): Development of a 13C-Urea “breath-test” for non invasive Helicobacter Pylori infection diagnosis (Expirobacter) and gastric empting, 2000-2004

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Palmera Spa (Milan): Improved and validated analytical methods for tuna fish identification and for the analysis of micro pollutants in meat, 2000-2004

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Zambon-Group Spa (Milan): Development and validation of a new analytical method for bio equivalence studies of UDCA, 2004

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Giuliani Spa (Milan): Design and development of new chemical entities: bile acids analogues, the studies of their physicochemical and biological properties “in vitro”, experimental animals and humans and the development of analytical methods suitable for their analysis in biological fluids. Evaluation of antioxidant properties of new natural compounds (Patents), 1990-2002

    Scientific Institutions:

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Collaboration with Istituto zooprofilattico di Teramo for the development of immunoenzymatic assays for the analysis of chemical drug residues in meat and foods. (See publications)

bulletConsulting activity with private and public institution regarding the selection of analytical methods and tests to solve their problems.

    Bilateral collaboration:

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2003-present Collaboration with the Connecticut College, New London, USA concerning exchange scientist and teaching project

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1999: Galileo Project: bilateral scientific exchange between Italy an France: collaboration with the CNRS of Strasbourg, France

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1997: Collaboration Italy-Britain for Advanced teaching and research

Scientific Activity

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Development of ultra sensitive bio-, chemi- and electrochemiluminescent analytical methods and immunoassays applied to biomedical, agro-food, environmental and cultural heritage samples; multiplex assay formats for food analysis including pathogen bacteria detection.

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Optimization of HTS methods for drug screening, toxicity tests, surrogate end points and in general for fast rapid and miniaturized assays.

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Development of new portable device for multiplexed detection based on luminescence and using microfabrication technology and microfluidics.

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Ultrasensitive ICH and ISH luminescence imaging, also in multiplexed and quantitative formats, for the localization of analytes in tissues or single cells.

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Molecular imaging in whole animals using genetically modified bioluminescent cells.

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Development of whole-cell luminescent biosensors and BRET technology for the quantification of toxic compounds or pollutants in biological or environmental samples and for drug screening

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Development of olfactive sensor (“electronic nose”)- and piezoelectric microbalance (QCM)-based analytical methods for quality control analysis on food, raw materials, formulations.

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Development of chromatographic methods coupled with Mass Spectrometry (HPLC-ES-MS/MS). Applications in environmental, biomedical, agro food and pharmaceutical analysis. ADME and bioequivalence study for new drugs and formulations.

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HPLC analysis with UV-Vis array, fluorescence, light scattering electrochemical detectors for drug analysis in row material and biological samples.

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Development of 13C- and H2-based breath tests for rapid non-invasive evaluation of motor and organ functions of the gastrointestinal system.

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Protein analysis and identification (proteomics) using bidimensional HPLC and gel electrophoresis and pre-analytical separation with FFF techniques coupled with mass spectrometry (MALDI-TOF and ESI-Q-TOF). Protein finger printing and new biomarker discovery.

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Bile acids: physical chemical properties, analysis in complex biological matrix, new analogues screening, ADME.

Bibliography

    Invited lectures (selection)

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In vivo molecular bioluminescence functional imaging: a new potent tool for drug development and screening. International Meeting RDPA 2009 Recent Developments in Pharmaceutical Analysis, Milan (Italy), 9-12 September 2009

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Molecular Bioluminescence imaging. 4th International Workshop on Biosensors For Food Safety And Environmental Monitoring Tangier (Morocco), 1-3 October 2009

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Novel BRET-based biosensors with a new bioluminescent donor, Gaussia luciferase, for estrogens and androgen receptor ligands. 14th International Symposium on Bioluminescence & Chemiluminescence, Yokohama (Japan), 15-19 October 2006.

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Quantitative immunohistochemistry and in situ hybridization imaging procedures with luminescence detection: a new potential diagnostic tool. XII International Symposium on Luminescence Spectrometry. Detection Techniques in Biomedical, Environmental and Food Analysis, Lugo (Spain), 18 – 21 July 2006

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Bioluminescence resonance energy transfer (BRET) nanotechnology: a tool for protein interaction studies. XII International Symposium on Luminescence Spectrometry. Detection Techniques in Biomedical, Environmental and Food Analysis, Lugo (Spain), 18 – 21 July 2006.

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Molecular imaging using luminescent probes, Okayama (Japan) October 1, 2005

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Bioluminescent biosensors based on genetically engineered living cells in environmental and food analysis. Second International Workshop on Biosensors for Food Safety and Environmental Monitoring, Agadir (Marocco), 10–12 November 2005.

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Molecular bio-chemiluminescence imaging. XII Hungarian-Italian Symposium on Spectrochemistry: Environmental Pollution and Human Health, Pécs (Hungary), 23–27 October 2005.

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Analytical proteomics using soft impact mass spectrometry. XII Hungarian-Italian Symposium on Spectrochemistry: Environmental Pollution and Human Health, Pécs (Hungary), 23–27 October 2005.

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Luminescent probes for sensitive and specific optical microscope imaging. 13th International Symposium on Bioluminescence & Chemiluminescence, Yokohama (Japan), 2-6 August 2004.

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A novel lanthanide chelate tag for ultrasensitive time-resolved fluorescence microscopy imaging of tissues and cells. 32nd Annual Meeting of the American Society for Photobiology, Seattle (USA), 10-14 July 2004.

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Analytical Luminescence, Connecticut College, New London, USA, 9 July 2004

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A novel microtiter plate format for single-well simultaneous multi-analyte chemiluminescent detection: application for the development of a PCR assay for typing human papilloma virus DNA. 12th International Symposium on Bioluminescence and Chemiluminescence, Cambridge (UK), 5-9 April 2002

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Novel strategies for the sampling and screening of dredged contaminated sediments, NSF-INCA Workshop Arlington, USA December 9-10, 2002

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Ultrasensitive luminescence microscope imaging in biosciences, CNRS Strasbourg, France 2002

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Analytical Bio-Chemiluminescence University of Limoges, France 2001

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Bile acids Metabolism and Pharmacological activity, Nicox, Sophia Antipolis, Nice , France 2001

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he Innovation in micotoxin analytical tests. X International Symposium of World association of Veterinary Laboratory Diagnosticians, Parma, 5 Luglio 2001

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Development of a time-resolved fluorescence microscope for imaging analysis. 11th International Symposium on Bioluminescence and Chemiluminescence, Asilomar, CA, September 6-10, 2000

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Analytical performance and applications of microscope-low light imaging using chemiluminescence and time-resolved fluorescence: immunohistochemical and in situ hybridization reactions. IX International Symposium on Luminescence Spectrometry, Montpellier, 15-17 May 2000

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Bile acid structure activity relationship, Mayo Clinic, Rochester MN, USA , 5 May 2000

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Modified bile acids. 3rd International Conference on Gallstones, Tiberias (Israel), 10-14 October 1999

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Breath testing: a non-invasive tool for the gastroenterologist. IIIrd International Workshop on Chronic Infections in Gastrointestinal Diseases, Rome, 1-2 July 1999.

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Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid induced cholestasis in rat. XV International Bile Acid Meeting: Bile Acids and Cholestasis, Titisee (Germany), October 12-13, 1998.

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Bio- and chemiluminescence imaging in bioanalysis. Drug Analysis ’98, Brussels, Belgium, May 11-15, 1998.

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Detection of biospecific reactions by chemiluminescent imaging. Symposium on Medical Biotechnology. Szeged, Hungary, March 29-31, 1998.

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Ultrasensitive bio- and chemiluminescent imaging using an optical microscope-videocamera luminograph: applications in biosciences and drug screening. Luminescence Assays for Industry, Cambridge, UK, September 22-23, 1997.

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Quantitative high performance low-light imaging in biosciences. Institute of Hydrochemistry, Technical University of Munich, 14th April 1997.

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Quantitative high performance low-light imaging in biosciences. Euroanalysis IX, Bologna, September 1-7, 1996

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Chemiluminescence imaging as a bioanalytical tool. J Biolumin Chemilumin, 11, 264, 1996. 9th International Symposium on Bioluminescence and Chemiluminescence, Woods Hole, October 4-8, 1996.

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Antioxidants properties of Bile Acids, International Symposium on Gastroenterology San Paolo Brasil, 1996

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HPLC-electrospray-mass spectrometry of the artificial sweetener aspartame and use of a post-column photochemical reactor. 33rd International Congress on Forensic & 1st on environmental toxicology (gretox 1995), August 27-31 1995, Thessaloniki, Greece.

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Use of termostable luminescent bacteria as a rapid cytotoxicity test. 8th International Symposium on Bioluminescence and Chemiluminescence, Cambridge, UK, September 5-8, 1994

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Improved intestinal absorption of an enteric-coated sodium ursodeoxycholate formulation. XIII International Bile Acid Meeting - Bile Acids in Gastroenterology: Basic and Clinical Advances, San Diego (USA), 30 settembre-2 October 1994.

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Analytical performance of a new highly sensitive luminometer. VIIth International Symposium on Bioluminescence and Chemiluminescence, Banff, Alberta, Canada, March 14-18, 1993.

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SAR on Bile Acids, NIH, Warrenton, Virginia Airlie House USA April 1989

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Relationship between physicochemical and biological properties of bile acids in solution. 32nd IUPAC Congress, Stockholm, Sweden, August 27, 1989

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36. Physicochemical and Physiological properties of New bile acids analogues, Advances in Bile acids Therapy, Vail Colorado USA August 26-27,1988

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Recent acquisitions on serum bile acids: methods development and clinical applications, Institute J.Curie, Budapest Hungry, 1985

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Recent acquisitions on the Chemistry and Physiology of bile acids, Chinese National academy of Science, Beijing China, 1982

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Physical-Chemistry of bile salt solutions, University of New Delhi, India, 1982

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Recent Acquisition on the analysis of bile acids by HPLC, workshop on HPLC: application in Biology and Pathology, Locarno Switzerland, 1982

    Patent co-inventorship

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Michelini E, Roda A, Dolci LS, Mezzanotte L, Cevenini L “Portable device with immobilized cells for the detection of substances”, Patent RM2009/A000064, 2009

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Branchini BR, Southworth TL, De Angelis J, Michelini E, Roda A “Isolated luciferase gene of L.italica”, US Patent # WO/2007/095108, 2007

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Branchini B.R., Southworth T.L., De Angelis J., Michelini E., Roda A.: Isolated luciferase gene of L. italica, US102816-100, 2006.

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Charbonniere L., Ziessel R., Wiebel N., Roda A., Guardigli M.: Lanthanide bis(carboxybipyridylmethyl)aminoalkanedicarboxylate complexes and analogs, their preparation and their uses as fluorescence markers and NMR relaxation agents, WO2005/014581, 2005.

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Crespi Petrellino N., Danieli B., Roda A., Bondi M., Marchioretto I.D., Minghetti A.: Compounds with an antioxidant acitivity, compositions useful as food integrators containing them and process for their preparation (Giuliani SpA, IT), ITMI20000066, 2001.

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Rodriguez L., Passerini N., Roda A.: Procedimento per l'intima associazione di preparazioni attive di un vettore solido, apparecchiatura che realizza tale metodo e prodotti così ottenuti (Ascor Chimici srl, IT), IT1306015, 2001.

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Roda A., Paolini M.: Acidi biliari come induttori del sistema citocromo p450-dipendente, in particolare ad attivita' anticolestatica, IT1299270, 2000.

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Berlati, Fabio; Ceschel, Giancarlo; Roda, Aldo; Roda, Enrico; Ronchi, Celestino; Nor- and homo- bile acids derivatives as absorption enhancers for medicaments US 5656277

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Pellicciari R., Roda A.: Bile acid unsaturated derivatives processes for the preparation thereof and pharmaceutical compositions containing them (Giuliani SpA, IT), HK1006313, 1999.

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Lorenzo L., Roda A.: Procedimento per l'intima associazione di preparazioni attive a un vettore solido, apparecchiatura che realizza tale metodo e prodotti cosi' ottenuti (Giuliani SpA, IT), ITBO980236, 1999.

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Cainelli G., Milani M.R., Marchi E., Piani S., A. Roda: Bile acids derivatives useful in the therapy of the biliary calculosis from cholesterol and of the pathologies caused by cholestasis (Alfa Wassermann SpA, IT), GR3025811T, 1998.

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Roda A., Bonaldi A., Molinari E.: Process for the preparation of glycine-conjugated bile acids and relative pharmaceutical compositions useful for treating hepatic insufficiency (Erregierre Ind. Chim., IT), DE69321177D, 1998.

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Ceschel G., Berlati F., Roda A., Roda E., Ronchi C.: Nor- and homo- bile acids derivatives as absorption enhancers for medicaments (Monteresearch srl, IT), DK652773T, 1998.

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Roda A., Bonaldi A., Molinari E.: Verfahren zur herstellung glycin-konjugierter gallensäure (Erregierre Ind. Chim., IT), AT171458T, 1998.

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Berlati F., Ceschel G., Roda A., Roda E., Ronchi C.: Anwendung von nor- und homo-gallensäurederivaten als absorptienförderer für arzneimittel (Monteresearch srl, IT), AT161731T, 1998.

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Marchi E., Milani M.R., Piani S., Roda A., Cainelli G.: Gallensäurederivate zur behandlung von gallenwegsteinen von cholesterin und davon verursauchte pathologien (Alfa Wassermann SpA, IT), AT160785T, 1997.

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Frigerio G., Roda A., Roda E.: Pharmaceutical compositions for the treatment of hypercholesterolemiae (Chemical and Biolog. Ind. Limited, IE), ITMI952686, 1997.

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Frigerio G., Roda A., Roda E.: Composizioni farmaceutiche per il trattamento delle ipercolesterolemie (Chemical and Biolog. Ind. Limited, IE), IT1277117, 1997.

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Bonaldi A., Molinari E., Roda A.: Process for the preparation of glycine-conjugated bile acids (Erregierre Ind. Chim., IT), US5616741, 1997.

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Frigerio G., Roda A., Roda E.: Composizioni farmaceutiche per il trattamento delle epatopatie croniche (Chemical and Biolog. Ind. Limited, IE), IT1277118, 1997.

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Giuliano G., Aldo A., Roda E.: Pharmaceutical compositions for the treatment of chronic hepatoses (Chemical and Biolog. Ind. Limited, IE), ITMI952687, 1997.

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Pellicciari R., Roda A., Frigerio G.: Gallensäure-derivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen daraus (Giuliani SpA SpA, IT), AT124953T, 1995.

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Pellicciari R., Roda A., Frigerio G.: Fluorierte gallensäure-derivate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen daraus (Giuliani SpA, IT), AT131173T, 1995.

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Berlati F., Ceschel G., Clerici C., Pellicciari R., Roda A., Ronchi C.: The use of bile acids as antiviral agents (Montefarmaco SpA, IT), WO9400126, 1994.

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Frigerio G., Roda A., Pellicciari R.: Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten (Istituto D. Giuliani SpA, IT), AT75750T, 1992.

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Frigerio G., Roda A., Roda E.: Complex of products for the rapid and non-invasive treatment of biliary calculosis (Giuliani SpA, IT), DE3777559D, 1992.

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Frigerio G., Roda A., Pellicciari R.: Billiary acid derivatives, processes for the preparation thereof and phamaceutical compositions containing them (Gipharmex SpA, IT), DE3870801D, 1992.

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Frigerio G., Roda A., Roda E.: Produktekomplex fuer die schnelle und nicht eindringende behandlung von gallensteinen (Giuliani SpA, IT), AT73661T, 1992.

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Pellicciari R., Roda A., Frigerio G.: Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them (Giuliani SpA, IT), US5175320, 1992.

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Pellicciari R., Roda A., Frigerio G.: Bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them (Giuliani SpA, IT), US5166374, 1992.

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Frigerio G., Pellicciari R., Roda A.: Fluorinated bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them (Giuliani SpA, IT), IT1229570, 1991.

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Frigerio G., Pellicciari R., Roda A.: Bile acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them (Giuliani SpA, IT), IT1229569, 1991.

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Castagnola V., Frigerio G., Pellicciari R., Roda A.: Gallensaeure-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die sie enthalten (Gipharmex SpA, IT), AT50583T, 1990.

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Castagnola V., Frigerio G., Pellicciari R., Roda A.: Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions (Gipharmex SpA, IT), DE3481419D, 1990.

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V. Castagnola, G. Frigerio, R. Pellicciari, A. Roda: Derivatives of biliary acids, process for the production thereof and corresponding pharmaceutical compositions (Gipharmex SpA, IT), US4892868, 1990.

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